Cytiva GE Hollow Fiber Filter Tangential Flow Cartridge 0.2um 110cm2

Description

Cytiva Xampler™ CFP-2-E-3MA Hollow Fiber TFF Cartridge (0.2 µm, 110 cm²)

The Cytiva Xampler™ CFP-2-E-3MA is a premier laboratory-scale Tangential Flow Filtration (TFF) device designed for the rapid clarification, sterilization, and concentration of biological fluids. This cartridge features a 0.2 µm microfiltration membrane, the industry standard for the removal of bacteria and large cellular debris. Engineered with Low Adsorption Polyethersulfone (PES) and a 110 cm² surface area, the Xampler™ provides a high-flux, low-fouling environment that ensures maximum product recovery. Its “Size 3” geometry and 1.0 mm fiber lumen make it an essential tool for R&D labs performing process development for vaccines, monoclonal antibodies, and recombinant proteins.

Technical Performance and Design

• 0.2 µm Microza PES Membrane: The 0.2 µm pore size is specifically validated for bacterial retention and sterile-grade clarification, offering a high-capacity alternative to traditional flat-sheet or pleated filters.

• 1.0 mm “A” Lumen Diameter: The wider 1.0 mm internal fiber diameter is designed to accommodate feed streams with high biomass or suspended solids, significantly reducing the risk of lumen plugging and pressure spikes.

• Low Protein Binding: The hydrophilic PES membrane chemistry minimizes non-specific interaction with biological analytes, maintaining high flux rates and preventing the “vanishing” of low-concentration proteins.

• Xampler™ Lab-Scale Efficiency: With an 110 cm² effective filtration area, this cartridge is optimized for processing sample volumes from 100 ml to 2 Liters, providing a reliable bridge between benchtop discovery and pilot-scale production.

Product Specifications

• Catalog Number: CFP-2-E-3MA (56-4101-73)

• Pore Size: 0.2 µm (Microfiltration)

• Membrane Area: 110 cm²

• Lumen ID: 1.0 mm

• Materials: PES Membrane; Polysulfone (PS) Housing

• Connections: 1/2-inch TC (Process) and Hose Barb (Permeate)

• Sterility: Non-sterile (Autoclavable; compatible with NaOH sanitation)

Key Benefits & Applications

• Bacterial & Yeast Clarification: Ideally suited for harvesting E. coli or yeast cells from fermentation broth while allowing smaller proteins to pass freely into the permeate.

• Sterile Filtration Pre-step: Used as a robust pre-filter to protect expensive downstream 0.1 µm or 0.22 µm pleated cartridges from premature fouling by colloidal matter.

• Gentle Processing: The hollow fiber architecture provides uniform shear and a gentle flow path, which is critical for maintaining the structural integrity of large proteins and sensitive viral vectors.

• Linear Scalability: The Xampler™ series is designed for “predictive scale-up,” ensuring that data generated in the lab can be directly translated to larger 4MA or production-scale modules.

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