Sartorius SartoScale Sartoguard PES 0.2 um Pack of 4 Filters

Description

Sartorius 5445307FS–FF–M SartoScale Sartoguard PES 0.2 µm Filter

The Sartorius 5445307FS–FF–M is a precision scale-down filtration tool engineered for filterability studies and the optimization of pre-filtration stages in biopharmaceutical manufacturing. Featuring the Sartoguard PES heterogeneous double-layer membrane, this unit combines a 1.2 µm pre-filter with a 0.2 µm bioburden reduction layer. This specific architecture is designed to capture high loads of particulates and colloidal matter, protecting expensive downstream sterilizing-grade filters from premature fouling. The SartoScale format (Size M) provides an effective filtration area of 17.3 cm², utilizing the exact same membrane and support fleece as full-scale Sartoguard cartridges to ensure reliable, linear scale-up and predictable process performance.

Technical Performance and Design

• Heterogeneous PES Membrane: The 1.2 µm + 0.2 µm combination offers an ideal balance of high dirt-holding capacity and significant bioburden reduction, achieving a typical Log Reduction Value (LRV) of 6 per cm² for Serratia marcescens.

• High-Efficiency Pre-Filtration: By removing the bulk of contaminants before the final sterile filter, Sartoguard PES units drastically increase total process throughput and reduce the total number of filters required for large-scale batches.

• Validated SartoScale 47 Format: With a 17.3 cm² filtration area, this unit is optimized for Vmax testing and material screening using minimal product volumes, delivering data that translates directly to production-scale capsules and cartridges.

• Low Non-Specific Binding: The polyethersulfone membrane chemistry ensures minimal interaction with valuable proteins and active pharmaceutical ingredients (APIs), maximizing yield and product stability.

Product Specifications

• Catalog Number: 5445307FS–FF–M

• Media Type: Sartoguard PES (Polyethersulfone)

• Pore Size: 1.2 µm (Pre-filter) + 0.2 µm (Final-filter)

• Effective Filtration Area (EFA): 17.3 cm² (Size M / Sartoscale 47)

• Connectors: 3/4″ (25 mm) Sanitary Tri-Clamp Inlet / 3/4″ (25 mm) Sanitary Tri-Clamp Outlet

• Housing Material: Polypropylene (PP)

• Sterility: Non-sterile (Autoclavable at 121°C or 134°C)

• Regulatory Compliance: Meets USP Class VI; Certified Non-pyrogenic and Non-fiber releasing.

Key Benefits & Applications

• Bioburden Reduction: Highly effective for reducing microbial loads in protein-based therapies and vaccine intermediates before final sterile fill/finish.

• Protection of Sterilizing Filters: Functions as a robust guard filter for Sartopore® 2 or Sartopore® Platinum final filters, preventing “blinding” in complex or high-viscosity media.

• Process Development: The essential tool for determining the optimal pre-filter to final-filter ratio, helping to minimize footprint and reduce overall process costs.

• Buffer & Media Clarification: Ideal for clarifying nutrient-rich cell culture media or complex buffers containing lipids and large molecular aggregates.

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