Description
Description
Ampicillin Sodium Salt Powder Or Crystals Bioreagent 25 Gram
Cas#: 69-52-3
Catalog #: J63807
Synonyms: 200-708-1, 69-52-3, Ampicillin sodium, Ampicillin sodium salt
Molecular Formula: C16H18N3NaO4S
Ampicillin sodium salt is the sodium salt form of ampicillin, which is classified as a broad-spectrum semisynthetic derivative of aminopenicillin. This organic sodium salt functions as an orally active antibiotic. Ampicillin sodium inhibits bacterial cell wall synthesis through the binding of penicillin binding proteins, therefore functioning as a critical component of the bacterial cell wall.
Ampicillin Sodium Salt, with a trade name of Principen, is an antibiotic. Non-graded Ampicillin Sodium Salt supplied by Spectrum is indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use..
Resources
- National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 23663979, Ampicillin sodium. Retrieved July 27, 2022 from .compound/23663979.
- Zhang Y, Trissel LA. Stability of Ampicillin Sodium, Nafcillin Sodium, And Oxacillin Sodium in AutoDose Infusion System Bags. Int J Pharm Compd. 2002 May-Jun;6(3):226-9. PMID: 23979189.
Synonym:D-(−)-α-Aminobenzylpenicillin sodium salt
- CAS Number 69-52-3
- Empirical Formula (Hill Notation) C16H18N3NaO4S
- Molecular Weight 371.39
- Beilstein/REAXYS Number 4119211
- EC Number 200-708-1
- MDL number MFCD00064313
- PubChem Substance ID 24890405
- NACRES NA.76
| biological source | synthetic |
| product line | BioReagent |
| form | powder or crystals |
| potency | 845-988 μg per mg (C16H18N3O4S, Calculated on the anhydrous basis) |
| application(s) | cell culture | mammalian: suitable |
| color | white to off-white |
| mp | 215 °C (dec.) (lit.) |
| solubility | H2O: 50 mg/mL (Stock solutions should be stored at −20 °C.) |
| Mode of action | cell wall synthesis | interferes |
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| storage temp. | 2-8°C |
| SMILES string | [Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O |
| InChI | 1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1 |
| InChI key | KLOHDWPABZXLGI-YWUHCJSESA-M |
General description
Chemical structure: ß-lactam
Application
Ampicillin is a semi-synthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.
Recommended for antibacterial use in cell culture media at 100 mg/L.
Recommended for use in ampicillin-resistance studies at 20-125 μg/ml.
Biochem/physiol Actions
Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it.
Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.
GHS08
Signal word Danger
Hazard statements H317-H334
Precautionary statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XH8400000
Documents
Safety Data Sheet
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