Millipore Filter Capsule Polysep II Opticap XL 5 MCE 0.2 um

Description

Millipore KGW3A05HH1 Opticap® XL 5 Polysep™ II 0.2 µm Filter Capsule

The Millipore KGW3A05HH1 is a high-capacity, heterogeneous double-layer capsule filter designed for the efficient bioburden reduction and clarification of biopharmaceutical process fluids. Part of the Opticap® XL 5 family, this unit utilizes Polysep™ II media, which combines a 1.0 µm pre-filter with a 0.2 µm final layer, both composed of high-purity Mixed Cellulose Esters (MCE). This unique “built-in pre-filtration” design provides significantly higher total throughput and dirt-holding capacity compared to single-layer filters, making it ideal for processing nutrient-rich cell culture media, complex buffers, and biological intermediates. Featuring robust 9/16″ (14 mm) hose barb connections, this capsule is engineered for seamless integration into flexible tubing manifolds and single-use assemblies.

Technical Performance and Design

• Heterogeneous MCE Double-Layer: The 1.0/0.2 µm graduated pore structure effectively captures a wide range of particulate sizes, protecting the final 0.2 µm layer from premature fouling and extending the filter’s service life.

• Opticap® XL 5 Thermal Stability: Constructed with a high-durability polypropylene housing that can withstand up to 3 autoclave cycles (30 min @ 121 °C), allowing for flexible sterilization options in clinical and research settings.

• Enhanced Flow Dynamics: The XL 5 format provides a generous 0.19 m² (2.0 ft²) of effective filtration area, delivering high flux rates and reducing the time required for large-volume batch processing.

• Low-Extractable Construction: Manufactured without the use of adhesives or surfactants, ensuring an exceptionally clean filtrate with minimal interference in sensitive protein purification or analytical assays.

Product Specifications

• Catalog Number: KGW3A05HH1

• Media Type: Polysep™ II (Mixed Cellulose Esters / MCE)

• Pore Size: 1.0 µm (Pre-filter) / 0.2 µm (Final-filter)

• Format: Opticap® XL 5 Capsule (5-inch nominal length)

• Inlet/Outlet: 9/16 inch (14 mm) Hose Barb

• Filtration Area: 0.19 m² (2.0 ft²)

• Max Pressure: 5.5 bar (80 psi) @ 23 °C; 1.0 bar (15 psi) @ 80 °C

• Purity: Certified Non-pyrogenic (≤0.5 EU/mL); Meets USP Class VI Biological Reactivity tests.

Key Benefits & Applications

• Bioburden Reduction: Highly effective at reducing microbial loads in vaccine intermediates and plasma-derived proteins prior to final sterilizing filtration.

• Media & Buffer Clarification: Optimized for filtering serum-supplemented media and complex buffers where standard 0.2 µm filters typically “blind” or clog too quickly.

• Particulate Removal: The depth-filtration characteristics of the MCE pre-filter layer make it excellent for removing colloidal matter and lipid aggregates from biological samples.

• Flexible Process Scaling: The 9/16″ hose barb design allows for rapid connection to standard silicone or TPE tubing, facilitating easy implementation in both R&D and pilot-scale production lines.

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