Millipore Mobius Mix Sample Disposable Assembly 500L Single Use

Description

Millipore Mobius MIX500 Single-Use Mixing and Sampling Assembly – 500 L, Levitating Magnetic Impeller, Needle-Free Sample Ports (MPN: MIX0500L1437887-SP)

Expired product – for R&D and process design purposes.

The Millipore Mobius MIX0500L1437887-SP is a premium, bioprocess-grade 500 Liter single-use mixing and sterile sampling container assembly engineered for high-security fluid processing in biopharmaceutical manufacturing, vaccine production, and upstream/downstream buffer preparation. Fabricated from multi-layer PureFlex high-durability film, this single-use bag features an integrated, bottom-mounted levitating magnetic impeller that operates without mechanical shafts or bearings to eliminate internal seal friction, particulate shedding, and contamination risk. Optimized for shear-sensitive ingredients, intermediate drug pooling, and media homogenization, this closed system incorporates built-in needle-free sampling valves to enable representative fluid draws without compromising the aseptic process environment.

Technical Performance and Design

• Levitating Magnetic Impeller Technology: Features a bottom-mounted, magnetically coupled impeller that floats during operation. By removing mechanical shafts, bearings, and direct physical contact, this design delivers low-shear mixing while minimizing the risk of bag leaks or particulate contamination.

• PureFlex Multi-Layer Film Construction: Fabricated from ultra-pure, multi-layer co-extruded PureFlex film. This film structure combines an inert polyethylene fluid contact layer with a high-durability woven nylon strength barrier to deliver exceptional flexibility, high mechanical strength, and an ultra-low extractables profile.

• Zero Dead-Leg Sterile Sampling: Equipped with specialized needle-free sample ports that interface directly with the mixing container. This design eliminates liquid stagnation zones, ensuring that extracted samples are completely representative of the entire 500 L process volume while protecting against cross-contamination.

• Closed System Process Efficiency: Eliminates the labor-intensive Clean-in-Place (CIP) and Steam-in-Place (SIP) validation cycles required by traditional stainless steel bioreactors and mixing vats. This single-use design enables rapid multi-product turnaround times and reduces operational downtime.

Product Specifications

• Catalog Number / MPN: MIX0500L1437887-SP (MIX0500L Series)

• Manufacturer / Brand: MilliporeSigma / Merck KGaA

• Nominal Processing Volume: 500 Liters (500 L)

• Assembly Type: Single-Use Mixing and Sampling Liner Bag

• Film Material Technology: PureFlex Multi-Layer Film (Polyethylene fluid-contact layer)

• Impeller Configuration: Integrated bottom-mounted magnetic impeller (Polypropylene encasement)

• Sampling Interface: Integrated needle-free sample valves

• Sterility / Purity Profile: Gamma irradiated sterile, pyrogen-free, and certified non-cytotoxic for bioprocessing compliance

Key Benefits and Applications

• Biopharmaceutical Media and Buffer Prep: The industry-standard vessel liner for the large-scale homogenization of complex cell culture medias, diagnostic buffers, and intermediate chemical processing reagents.

• Shear-Sensitive Homogenization: The levitating magnetic drive provides gentle yet highly efficient fluid movement, making it ideal for mixing sensitive protein solutions, monoclonal antibodies, and viral vaccines without structural degradation.

• Representative Diagnostic Pulls: Built-in sampling channels allow production teams to perform closed-loop pH, conductivity, and purity checks directly from the main batch fluid lines without introducing ambient contamination.

• Mobile Carrier Compatibility: Engineered to align with standard Mobius MIX500 hardware carriers and automated drive units, ensuring secure outer support, load-cell alignment, and rapid inflation deployment.

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