Pall Filter Capsule AcroPak 500 Supor Membrane Box of 2 Filters

Description

Pall 12997 AcroPak 500 Filter Capsule – 0.1/0.1 µm, Supor PES Membrane, Sterile

The Pall 12997 AcroPak 500 is a high-capacity, sterilization-grade filter capsule designed for the rapid processing of large volumes of biological fluids and aqueous solutions. Featuring a double-layer 0.1/0.1 µm Supor (polyethersulfone) membrane, this capsule is specifically optimized for mycoplasma reduction and the sterile filtration of cell culture media, buffers, and protein-containing solutions. The Supor membrane is inherently hydrophilic and offers exceptionally low protein binding, ensuring maximum recovery of high-value active ingredients. With an effective filtration area of 500 cm², the 12997 provides high throughput and fast flow rates for volumes up to 150 liters, making it a critical component for biopharmaceutical R&D and pilot-scale production.

Technical Performance and Design

• Mycoplasma Reduction: The dual-layer 0.1 µm membrane architecture is validated to provide a high level of mycoplasma removal, offering superior protection compared to standard 0.2 µm sterilizing filters.

• High-Flow Supor PES Membrane: The asymmetric pore structure of the Supor membrane delivers significantly higher flow rates and lower pressure drops, reducing processing time and increasing overall laboratory efficiency.

• Low Protein Binding: Specifically engineered to minimize the adsorption of proteins, enzymes, and other sensitive biological molecules, ensuring that the final filtrate maintains its intended potency and composition.

• Secure Connections & Housing: Constructed from high-purity polypropylene with stepped hose barb inlets and a filling bell on the outlet to protect the sterile filtrate during dispensing.

Product Specifications

• Catalog Number: 12997

• Series: AcroPak 500

• Membrane Type: Supor (PES)

• Pore Size: 0.1/0.1 µm (Double Layer)

• Effective Filtration Area: 500 cm²

• Connections: 6.4 – 12.7 mm (1/4 – 1/2 in.) Stepped Hose Barb with Filling Bell

• Sterility: Sterile (Gamma Irradiated)

Key Benefits & Applications

• Cell Culture Media Sterilization: The primary choice for filtering media and supplements where mycoplasma-free status is mandatory for maintaining long-term cell line health.

• Bioprocess Scale-Up: Designed to handle intermediate volumes (up to 150L) in a compact, disposable format that eliminates the need for filter housing cleaning and sterilization validation.

• High Turbidity Solutions: The high EFA (Effective Filtration Area) and robust membrane design allow for the efficient clarification of turbid solutions and cell lysates without premature clogging.

• Aseptic Filling: The included filling bell on the outlet serves as a protective shroud, significantly reducing the risk of airborne contamination during the transfer of sterile fluids into receiver vessels.

Manufacture date: 2017.

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