Research Antibiotics, Tipiracil Hydrochloride, 10mg

Description

Description

Tipiracil Hydrochloride, 10 mg.

Tipiracil is a member of the pyrimidone class. It inhibits the enzyme thymidine phosphorylase (TPase), which is an endothelial cell growth factor. It is used in combination with Trifluidine, since it inhibits the enzyme that metabolizes trifluridine, and Trifluridine/Tipiracil is used in colorectal cancer therapy.

• Category: Cancer Research
• CAS Number: 183204-72-0
• Molecular Formula: C₉H₁₁ClN₄O₂ • HCl
• Molecular Weight: 279.12
• Mechanism of Action: Tipiracil is a thymidine phosphorylase inhibitor and prevents conversion into the inactive major metabolite (5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione). Thus, the compound can increase trifluidine bioavailability in vivo.
• Storage Conditions: -20°C

Cancer Applications

The effects of trifluridine/tipiracil (TFTD) on the survival times of mice inoculated with human colorectal or gastric cancer cells into the peritoneal cavity were evaluated. Human cell lines were used in this study. Colon cancer cell line HT-29, colorectal carcinoma DLD-1 cells and HCT116 cells, 5FU-resistant cell line DLD-1/5FU , gastric cancer cell line MKN45. The compound exhibited anticancer activities and significantly prolonged survival in nude mice. (Suzuki et al, 2017).

Specifications

• Form: Powder
• Appearance: White to off-white powder
• Source: synthetic

References

Fukushima M (2000) Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides. Biochem Pharmacology. 59(10):1227-1236 PMID 10736423 Suzuki N, Nakagaa F and Takechi T (2017) Trifluridine/Tipiracil increases survival rate in peritoneal dissemination mouse models of human colorectal and gastric cancer. Oncol Lett. 14(1):639-646S

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.